Adipose-derived mesenchymal stem cells (AdMSCs) for the treatment of secondary progressive multiple sclerosis: A triple-blind, placebo-controlled, randomized phase I/II safety and feasibility study

Currently available treatments for secondary progressive multiple sclerosis (SPMS) have limited efficacy. Adipose-mesenchymal-derived stem cells (AdMSCs) represent a promising option and can be easily obtained with minimally invasive procedures.

In this placebo-controlled study, stem cell samples were harvested from consenting patients via lipectomy and subsequently expanded. Patients were given a single placebo, low-dose (1×106 cells/kg) or high-dose (4×106 cells/kg) infusion of autologous AdMSC product, and these patients were then monitored and followed for 12 months thereafter.

Thirty-four patients underwent lipectomy for collection of AdMSCs. They were then randomized and 30 were infused (11 with placebo, 10 with low dose, and 9 with high dose); 4 patients did not receive the infusion because of karyotype abnormalities in the cell product.

Only one contraindication emerged after infusion: urinary infection, considered, however, to be unrelated to the study at hand. No other “safety” parameters showed changes.

The study showed, therefore, that the infusion of autologous AdMSCs is safe and feasible in patients with SPMS. Larger studies in terms of number of participants and probably treatment at earlier stages of the disease would be needed to investigate the potential therapeutic benefit of this technique.

Stem Cell Storage: Intermediary companies fail, but there are still Biobanks to rely on like SSCB

“The failure and mismanagement of other Biobanks for Stem Cell Preservation ruin our sector”, speaks Dr. Luca Mariotta, Scientific Director of SSCB.
Last week, Ticinonews reported on a young couple who were looking for their baby’s cells after the company they had contracted with, Genico, disappeared. Cantonal pharmacist Giovan Maria Zanini said he was concerned about Switzerland’s free-market policy in such a sensitive area.

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Musculoskeletal disorders and mesenchymal stem cells

Considered to be one of the leading causes of disability worldwide, musculoskeletal disorders include osteoarthritis, rheumatoid arthritis, low back pain, osteoporosis, sarcopenia and myofascial pain syndrome. There are several clinical studies investigating the efficacy of mesenchymal stem cells in these musculoskeletal disorders (MSDs).

The safety of MSC treatment in humans with osteoarthritis, a chronic inflammatory joint disease, was evaluated in a study of 12 patients. All patients had chronic knee pain. Treatment was performed by intra-articular injection of expanded autologous bone marrow mesenchymal stem cells (BM-MSC).

91% of the patients showed an improvement in cartilage quality.

Furthermore, in another clinical study, some patients were treated with an intra-articular injection of allogeneic BM-MSC (from a donor) and the same results were observed as an increase in cartilage quality. 

These results were undoubtedly obtained thanks to the potential of mesenchymal stem cells which, thanks to the microenvironment of the damaged site, expressed key genes in cartilage development and type II collagen synthesis promoting cartilage regeneration.

Fat as a source of stem cells for regenerative and aesthetic medicine

Did you know that SSCB offers you the possibility to store stem cells from fat tissue? Fat tissue is a rich source of stem cells that are widely used in regenerative and aesthetic medicine. But how is fat tissue harvested? The fat is easily and safely harvested through mini-liposuction, which is performed by a doctor.

Thanks to this minimally invasive procedure, you can store your fat and avoid major liposuction or the use of synthetic fillers. 

Outcomes of mesenchymal stem cell transplantation from umbilical cord for the treatment of decompensated liver cirrhosis

group (n = 111) and cord blood mesenchymal stem cell infusion group (n = 108). Both groups were followed up for a follow-up period of 7 years (October 2010 to October 2017). Specifically, patients in the control group received only conventional therapy while patients in the other group received three infusions of mesenchymal stem cells from cord tissue at four-week intervals.

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