Significant Improvement of Acute Complete Spinal Cord Injury Patients Diagnosed by a Combined Criteria Implanted with NeuroRegen Scaffolds and Mesenchymal Stem Cells

stem-cells-neurological-disease

Stem cells and biomaterials transplantation hold a promising treatment for functional recovery in spinal cord injury (SCI) animal models. However, the functional recovery of complete SCI patients was still a huge challenge in clinic. Additionally, there is no clinical standard procedure available to diagnose precisely an acute patient as complete SCI. Here, two acute SCI patients, with injury at thoracic 11 (T11) and cervical 4 (C4) level respectively, were judged as complete injury by a stricter method combined with American Spinal Injury Association (ASIA) Impairment Scale, magnetic resonance imaging (MRI) and nerve electrophysiology. Collagen scaffolds, named NeuroRegen scaffolds, with human umbilical cord mesenchymal stem cells (MSCs) were transplanted into the injury site. During 1 year follow up, no obvious adverse symptoms related to the functional scaffolds implantation were found after treatment. The recovery of the sensory and motor functions was observed in the two patients. The sensory level expanded below the injury level, and the patients regained the sense function in bowel and bladder. The thoracic SCI patient could walk voluntary with the hip under the help of brace. The cervical SCI patient could raise his lower legs against the gravity in the wheelchair and shake his toes under control. The injury status of the two patients was improved from ASIA A complete injury to ASIA C incomplete injury.
Furthermore, the improvement of sensory and motor functions was accompanied with the recovery of the interrupted neural conduction. These results showed that the supraspinal control of movements below the injury was regained by functional scaffolds implantation in the two patients who were judged as the complete injury with combined criteria, it suggested that functional scaffolds transplantation could serve as an effective treatment for acute complete SCI patients.

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Stem cell therapy for stress urinary incontinence

stem cells urinary

Stress urinary incontinence is the involuntary loss of urine on effort or physical exertion. It is a highly prevalent condition affecting both men and women. Treatment is performed in a step-wise approach involving conservative measures, such as weight loss and pelvic floor exercises, medical treatment with duloxetine and a variety of surgical treatment options.

However, recent restrictions in the use of synthetic mesh and tape have limited the surgical treatment options, leading to the need for new and novel treatment for stress urinary incontinence. Stem cell therapy is a developing medical field and offers the potential to restore normal physiological function of the urethral sphincter.

The effectiveness of stem cell therapy in stress urinary incontinence has been demonstrated in pre-clinical studies, leading to its evaluation in several clinical studies.

This review assesses the current evidence for the safety and efficacy of stem cell treatment for patients with stress urinary incontinence who have failed conservative and/or medical management and have not undergone previous surgical treatment for stress urinary incontinence.

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Clinical feasibility of umbilical cord
tissue-derived mesenchymal stem cells
in the treatment of multiple sclerosis

stem cells multiple sclerosis

Multiple sclerosis (MS) is a progressively debilitating neurological condition in which the immune system abnormally erodes the myelin sheath insulating the nerves. Mesenchymal stem cells (MSC) have been used in the last decade to safely treat certain immune and infammatory conditions.

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Safety and efficacy of intracoronary human umbilical cord-derived mesenchymal stem cell treatment for very old patients with coronary chronic total occlusion

stem cells coronary chronic total occlusion

This study aimed to investigate the safety and feasibility of intracoronary injection of human umbilical cord mesenchymal stem cell to the very old patients with coronary chronic total occlusion 15 consecutive patients received mesenchymal stem cells from human umbilical cord in epicardial coronary artery supplying collateral circulation.

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Stem Cell Storage: Intermediary companies fail, but there are still Biobanks to rely on like SSCB

“The failure and mismanagement of other Biobanks for Stem Cell Preservation ruin our sector”, speaks Dr. Luca Mariotta, Scientific Director of SSCB.
Last week, Ticinonews reported on a young couple who were looking for their baby’s cells after the company they had contracted with, Genico, disappeared. Cantonal pharmacist Giovan Maria Zanini said he was concerned about Switzerland’s free-market policy in such a sensitive area.

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Musculoskeletal disorders and mesenchymal stem cells

Considered to be one of the leading causes of disability worldwide, musculoskeletal disorders include osteoarthritis, rheumatoid arthritis, low back pain, osteoporosis, sarcopenia and myofascial pain syndrome. There are several clinical studies investigating the efficacy of mesenchymal stem cells in these musculoskeletal disorders (MSDs).

The safety of MSC treatment in humans with osteoarthritis, a chronic inflammatory joint disease, was evaluated in a study of 12 patients. All patients had chronic knee pain. Treatment was performed by intra-articular injection of expanded autologous bone marrow mesenchymal stem cells (BM-MSC).

91% of the patients showed an improvement in cartilage quality.

Furthermore, in another clinical study, some patients were treated with an intra-articular injection of allogeneic BM-MSC (from a donor) and the same results were observed as an increase in cartilage quality. 

These results were undoubtedly obtained thanks to the potential of mesenchymal stem cells which, thanks to the microenvironment of the damaged site, expressed key genes in cartilage development and type II collagen synthesis promoting cartilage regeneration.